For what it's worth, I had CONTINUAL canker sores that were caused by a vitamin/iron deficiency caused in turn by calcium supplements. I had, on average, four to six at a time, for months straight, with no breaks between waves of sores. Eating without pain was a distant memory, and talking was frequently difficult. I tried many topical treatments and diet adjustments, and finally discovered that the calcium supplements I was taking could interfere with iron absorption. I stopped the calcium and started a daily multivitamin with iron, the current wave healed quickly, and I've been sore-free for a month now. Doubtless most people with chronic canker sores aren't taking calcium supplements, but I think the value of this example is to look into vitamin/iron deficiencies.
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