I have suffered from RLS for nearly 20 years. The best remedy I've found, and this is not meant to be glib, shallow or reactionary, is to have an orgasm. Seriously. I have a wonderful wife who has seen this to be true and obliges when she can, however during the week this is difficult, she has to be up early for work. When my RLS is really bad he doesn't mind going downstairs and using internet porn to achieve the desired goal. It may not work for all, but if you haven't tried this, i suggest it could be a revealation for some.
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